01 / DESIGN
What was studied?
This paper combines experiments involving mice of different ages, muscle-cell studies and measurements of naturally occurring MOTS-c in humans after exercise.
02 / FINDINGS
What did the researchers report?
Mouse experiments reported changes in physical performance and muscle stress responses. Human observations showed exercise-associated increases in endogenous MOTS-c in muscle and circulation.
03 / LIMITS
How should it be interpreted?
The human component did not demonstrate that giving MOTS-c improves performance or extends life. Observing a naturally occurring signal after exercise is different from establishing the effects of administering that signal.
Loti Labs Peptide editorial reading note. Based on the linked source record. Methods and corrections.